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B-hCCR2 mice
Strain Name C57BL/6-Ccr2tm1(CCR2)/Bcgen Common Name  B-hCCR2 mice
Background C57BL/6 Catalog number  110097
Related Genes 
CCR2 ( chemokine (C-C motif) receptor 2 )

Gene Description


The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. 


Protein expression analysis

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Strain specific CCR2 expression analysis in homozygous B-hCCR2 mice by flow cytometry. 
Bone Marrow were collected from WT and homozygous B-hCCR2 mice, and analyzed by flow cytometry with species-specific anti-CCR2 antibody. Mouse CCR2 was only detectable in WT mice. Human CCR2 was exclusively detectable in homozygous B-hCCR2 but not WT mice.