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B-hCCR4 mice
Strain Name C57BL/6-Ccr4tm1(CCR4)/Bcgen Common Name  B-hCCR4 mice
Background C57BL/6 Catalog number  170164
Related Genes 
CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5

Gene Description



C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. CCR4 has also recently been designated CD194 (cluster of differentiation 194). CCR4 belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines: CCL2, CCL4, CCL5, CCL17, CCL22. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. CCR4 is often expressed on leukemic cells in cutaneous T-cell lymphoma (CTCL). Mogamulizumab is a humanized monoclonal antibody targeted at CCR4 and is an investigational drug for CTCL.



mRNA expression analysis

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Strain specific analysis of CCR4 gene expression in WT and hCCR4 mice by RT-PCR. Mouse Ccr4 mRNA was detectable only in splenocytes of wild-type (+/+) mice. Human CCR4 mRNA was detectable only in H/H, but not in +/+ mice. 


Protein expression analysis in Tregs

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Strain specific CCR4 expression analysis in homozygous B-hCCR4 mice by flow cytometry. Splenocytes were collected from WT and homozygous B-hCCR4 (H/H) mice, and analyzed by flow cytometry with species-specific anti-CCR4 antibody. Mouse CCR4 was detectable in WT mice. Human CCR4 was exclusively detectable in homozygous B-hCCR4 but not WT mice.