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B-hCCR6 mice
Strain Name

C57BL/6-Ccr6tm1(CCR6)/Bcgen

Common Name 

B-hCCR6 mice

Background C57BL/6 Catalog number  

110853


Related Genes 

BN-1, DCR2, DRY6, CCR-6, CD196, CKRL3, GPR29, CKR-L3, CMKBR6, GPRCY4, STRL22, CC-CKR-6, C-C CKR-6


Gene description


CCR6 (C-C motif chemokine receptor 6, gene ID 1235), encoding a seven transmembrane protein similar to G protein-coupled receptors, expressed on B-cells, immature dendritic cells (DC), T-cells (Th1, Th2, Th17, Treg), natural killer cells (NKT cells) and neutrophils. This chemokine receptor bind only one chemokine ligand CCL20. CCR6 has a key role in connection between immature DC an adaptive immunity. It is important for B-lineage maturation, antigen-driven B-cell differentiation, and regulate the migration and recruitment of dendritic cells and T cells during inflammatory and immunological responses. Pro-inflammatory Th17 cells also express CCR6 and its ligand CCL20. CCR6 influences their migration to sites of inflammation. Some Th17 cells migrate via chemokine gradient of CCL20 to inflammatory sites and themselves can express more CCL20 to bring in more Th17 cells and regulatory T-cells. This can lead to chronic inflammation. In some models, the lack of CCR6 leads to less severe autoimmune encephalomyelitis.


Protein expression analysis


from clipboard


Strain specific CCR6 expression analysis in homozygous B-hCCR6 mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 (+/+)  and homozygous B-hCCR6 mice (H/H), and analyzed by flow cytometry with anti-CCR6 antibody. Mouse CCR6 was detectable in C57BL/6 mice. Human CCR6 was only detectable in homozygous B-hCCR6 mice but not in C57BL/6 mice.