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B-hCLDN6 mice

Strain Name

C57BL/6-Cldn6tm1(CLDN6)/Bcgen

Common Name 

B-hCLDN6 mice

Background C57BL/6 Catalog number  

 111086


Related Genes 

/


Gene description


CLDN6 (claudin 6, gene ID 9074) encodes a transmembrane protein forming the backbone of epithelial cell tight junctions, which is adjacent to another family member CLDN9 on chromosome 16, belongs to the claudin family. CLDN6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. The expression of CLDN6 in non-cancerous tissue is restricted to early stages of development, as in healthy adult tissues it is transcriptionally silenced. A fact which has led to consideration of CLDN6 as circulating marker for pregnancy. The protein is one of the entry cofactors for hepatitis C virus. The methylation of this gene may be involved in esophageal tumorigenesis. In various cancer types such as ovarian, lung, gastric, breast and pediatric cancers CLDN6 expression is aberrantly activated. Studies have shown that CLDN6 is associated with the proliferation migration and apoptosis of tumor cells and help to regulate defense and barrier functions, as well as  differentiation and polarity in epithelial and endothelial cells.


Protein expression analysis


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Strain specific CLDN6 expression analysis in heterozygous B-hCLDN6 mice by western blot. Liver tissue was collected from wild-type C57BL/6 (+/+) and heterozygous B-hCLDN6 mice (H/+) and analyzed by western blotting with species-specific anti-CLDN6 antibody. Mouse CLDN6 was detectable in wild-type mice and heterozygous B-hCLDN6 mice. Human CLDN6 was exclusively detectable in heterozygous B-hCLDN6 mice but not in wild-type mice.


Protein expression analysis


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Strain specific CLDN6 expression analysis in homozygous B-hCLDN6 mice by western blot. Liver tissue and thymus were collected from wild-type C57BL/6 (+/+) and homozygous B-hCLDN6 mice (H/H) and analyzed by western blotting with species-specific anti-CLDN6 antibody. Mouse CLDN6 was detectable in wild-type mice. Human CLDN6 was exclusively detectable in homozygous B-hCLDN6 mice but not in wild-type mice.