Strain Name |
C57BL/6-Igs2tm1(CEACAM8)Bcgen/Bcgen |
Common Name |
B-hCEACAM8 mice |
Background |
C57BL/6 |
Catalog Number |
112832 |
Aliases |
CD66b, CD67, CGM6, NCA-95 |
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NCBI Gene ID |
1088 |
Description
Targeting strategy
Gene targeting strategy for B-hCEACAM8 mice. The full coding sequences, promoter, 5’UTR and 3’UTR of human CEACAM8 gene are inserted into mouse Hipp11 (H11) locus in B-hCEACAM8 mice.
Protein expression analysis
Strain specific CEACAM8 expression analysis in homozygous B-hCEACAM8 mice by flow cytometry. Spleen, blood and bone marrow were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hCEACAM8 mice (H/H) and analyzed by flow cytometry with species-specific anti-human CD66b Antibody (Biolegend, 396906). Human CEACAM8/CD66b was detectable on neutrophils from spleen, blood and bone marrow of B-hCEACAM8 mice.