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B-hBCMA mice
Strain Name C57BL/6-Tnfrsf17tm2(TNFRSF17)/Bcgen Common Name  B-hBCMA mice
Background C57BL/6N Catalog number  110899
Aliases 
BCM, BCMA, CD269, TNFRSF13A

Gene description

BCMA is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.

mRNA expression analysis

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Strain specific analysis of BCMA gene expression in wild-type C57BL/6 mice and B-hBCMA mice by RT-PCR. Mouse Bcma mRNA was detectable in splenocytes of wild-type C57BL/6 mice (+/+) but not in homozygous B-hBCMA mice (H/H). Human BCMA mRNA was detectable only in homozygous B-hBCMA mice but not in wild-type C57BL/6 mice.