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B-hCD155 mice
Strain Name C57BL/6-Cd155tm1(CD155)/Bcgen  Common Name  B-hCD155 mice
Background C57BL/6 Catalog number  110759
Related Genes 
PVR, HVED, NECL5, Necl-5, PVS, TAGE4

Gene description


CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. As an immunoglobulin‐like adhesion molecule, CD155 is involved in cell motility, and natural killer and T cell‐mediated immunity. CD155 is barely or weakly expressed in various normal human tissues, but frequently overexpressed in human malignant tumors. CD155 overexpression promotes tumor cell invasion and migration, and is associated with tumor progression and poor prognosis. CD155 has also been established as an immunomodulatory receptor, able to both activate NK cells through interactions with CD226 (DNAM-1) and CD96 and inhibit them through interaction with TIGIT. 


mRNA expression analysis


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Strain specific analysis of CD155 gene expression in wild type (WT) and B-Hcd155 mice by RT-PCR. 
Mouse Cd155 mRNA was detectable only in splenocytes of wild type (+/+) mice. Human CD155 mRNA was detectable only in homozygous B-hCD155 but not in wild-type mice.

Protein expression analysis



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Strain specific CD155 expression analysis in homozygous B-hCD155 mice by flow cytometry. 
Peritoneal washing macrophage were collected from wild-type (+/+) and homozygous B-hCD155 (H/H) mice and analyzed by flow cytometry with species-specific anti-CD155 antibody. Mouse CD155 was detectable in wild-type mice. Human CD155 was exclusively detectable in homozygous B-hCD155 but not in wild-type mice.