请输入关键字
请输入关键字
订购
*国家
中国
美国
*省份
*城市
*姓名
*电话
*单位
*职位
*邮箱
*请输入验证码
*验证码
B-hCD226 mice
Strain Name C57BL/6-Cd226tm1(CD226)/Bcgen Common Name  B-hCD226 mice
Background C57BL/6 Catalog number   110869
Related Genes 
PTA1; DNAM1; DNAM-1; TLiSA1

Gene description


This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. CD226 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155,and cross-linking CD226 with antibodies causes cellular activation

Protein expression analysis



Strain specific CD226 expression analysis in heterozygous B-hCD226 mice by flow cytometry. Splenocytes were collected from WT and heterozygous B-hCD226(H/+) mice and analyzed by flow cytometry with species-specific anti-CD226 antibody. Mouse 226 was detectable in WT and heterozygous B-hCD226 mice. Human CD226 was exclusively detectable in heterozygous B-hCD226 but not WT mice.


from clipboard


Strain specific CD226 expression analysis in homozygous B-hCD226 mice by flow cytometry. Splenocytes were collected from wild type and homozygous B-hCD226 mice (H/H)  and analyzed by flow cytometry with species-specific anti-CD226 antibody. Mouse CD226 was detectable in wild type mice . Human CD226 was exclusively detectable in homozygous B-hCD226 but not wild type mice.