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B-hCD37 mice
Strain Name C57BL/6-Cd37tm1(CD37)/Bcgen Common Name  B-hCD37 mice
Background C57BL/6 Catalog number  110856
Aliases 
GP52-40, TSPAN26

Gene description

CD37 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. 

mRNA expression analysis


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Strain specific analysis of CD37 gene expression in wild-type C57BL/6 mice and homozygous B-hCD37 mice by RT-PCR. Mouse Cd37 mRNA was detectable in splenocytes of wild-type C57BL/6 mice (+/+). Human CD37 mRNA was detectable only in homozygous B-hCD37 mice (H/H) but not in wild-type mice. 

Protein expression analysis

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Strain specific CD37 expression analysis in wild-type C57BL/6 mice and homozygous B-hCD37 mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hCD37 mice (H/H) and B cells were selected with anti-mCD19 antibody.  Mouse CD37 was detectable only in wild-type mice. Human CD37 was detectable only in homozygous B-hCD37 mice.