请输入关键字
请输入关键字
订购
*国家
中国
美国
*省份
*城市
*姓名
*电话
*单位
*职位
*邮箱
*请输入验证码
*验证码
B-hCD47 mice(C)
Strain Name BALB/c-Cd47tm1(CD47)/Bcgen Common Name  B-hCD47 mice(C)
Background Balb/c Catalog number  110615
Aliases 
Cd47 (CD47 antigen)
Gene Description


CD47 is an integrin associated protein (IAP) and is an immunoglobulin superfamily member. CD47 is widely expressed on cell surface and interacts with the signal regulatory protein α (SIRPα), thrombospondin-1 (TSP1) and integrins to mediate a series of responses including apoptosis, proliferation and immunity. CD47 is an important “self” mark on the cell surface and inhibits macrophagocytosis by interaction with SIRPα on macrophage surface. Animal studies have shown that a CD47 antibody is an effective treatment for multiple types of tumors. CD47 is another target for tumor immunity following PD-1/PD-L1.


Protein Expression Analysis


from clipboard


Splenocytes from both wild type (WT) BALB/c and homozygous B-hCD47 (C) mice were analyzed by flowcytometry. 
Mouse CD47+ T cells were detectable in WT BALB/c, while human CD47+ T
cells were only detectable in the homozygous B-hCD47 (C) mice.