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B-hFCAR mice
Strain Name C57BL/6-Fcartm1(FCAR)/Bcgen Common Name  B-hFCAR mice
Background C57BL/6 Catalog number  110864
Related Genes 
CD89; FcalphaRI; CTB-61M7.2

Gene description


CD89, also known as FcαR, is a 55-100kDa glycosylated protein. It belongs to the immunoglobulin gene family. It is expressed on granulocytes, monocytes, and macrophages but is absent on T cells. It can interact with IgA aggregates and plays an important role in IgA mediated immune responses. This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Protein expression analysis


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Strain specific FCAR expression analysis in homozygous B-hFCAR mice by flow cytometry. 
Spleen, bone marrow and blood were collected from wild-type C57BL/6 mice (+/+)  and homozygous B-hFCAR mice (H/H), and analyzed by flow cytometry with anti-FCAR antibody. Human FCAR was detectable in NK cells of homozygous B-hFCAR mice.

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Strain specific FCAR expression analysis in homozygous B-hFCAR mice by flow cytometry. 
Spleen, bone marrow and blood were collected from wild-type C57BL/6 mice (+/+)  and homozygous B-hFCAR mice (H/H), and analyzed by flow cytometry with anti-FCAR antibody. Human FCAR was detectable in B cells of homozygous B-hFCAR mice.

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Strain specific FCAR expression analysis in homozygous B-hFCAR mice by flow cytometry. 
Spleen, bone marrow and blood were collected from wild-type C57BL/6 mice (+/+)  and homozygous B-hFCAR mice (H/H), and analyzed by flow cytometry with anti-FCAR antibody. Human FCAR was detectable in monocyte of homozygous B-hFCAR mice.