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B-hMCAM mice
Strain Name C57BL/6-Mcamtm1(MCAM)/Bcgen Common Name  B-hMCAM mice
Background C57BL/6 Catalog number  111168
Related Genes 
CD146, HEMCAM, METCAM, MUC18, MelCAM

Gene description

MCAM (melanoma cell adhesion molecule) was originally identified as a melanoma cell adhesion molecule (MCAM) and highly expressed in many tumors and endothelial cells. However, the evidence that CD146 acts as an adhesion molecule to mediate a homophilic adhesion through the direct interactions between CD146 and itself is still lacking. Recent evidence revealed that CD146 is not merely an adhesion molecule, but also a cellular surface receptor of miscellaneous ligands, including some growth factors and extracellular matrixes. Through the bidirectional interactions with its ligands, CD146 is actively involved in numerous physiological and pathological processes of cells. Overexpression of CD146 can be observed in most of malignancies and is implicated in nearly every step of the development and progression of cancers, especially vascular and lymphatic metastasis. Thus, immunotherapy against CD146 would provide a promising strategy to inhibit metastasis, which accounts for the majority of cancer-associated deaths. 

Protein expression analysis

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Strain specific MCAM expression analysis in homozygous B-hMCAM mice by western blot. 
Kidney, small intestine and testis were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hMCAM mice (H/H), and analyzed by western blot with anti-MCAM antibody. Mouse MCAM was detectable in wild-type mice. Human MCAM was exclusively detectable in homozygous B-hMCAM mice but not in wild-type mice.