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B-FcRn KO mice
Strain Name C57BL/6-Fcgrttm1/Bcgen Common Name  B-FcRn KO mice
Background C57BL/6 Catalog number  110165
Related Genes 
FCGRT(Fc fragment of IgG receptor and transporter)

Gene description

The neonatal Fc receptor (The neonatal Fc receptor (FcRn), which is similar in structure to the MHC class I molecule and also associates with beta-2-macroglobulin, it is found in the placenta to help facilitate transport of mother's IgG to the growing fetus in humans. FcRn extends the half-life of IgG and serum albumin by reducing lysosomal degradation in endothelial cells and bone-marrow derived cells. Neonatal Fc receptor expression is up-regulated by the proinflammatory cytokine, TNF-α, and down-regulated by IFN-γ.

mRNA expression analysis 

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Strain specific analysis of Fcgrt gene expression in C57BL/6(+/+)  and B-FcRn KO mice by RT-PCR.

Kidney was collected from C57BL/6(+/+) mice and homozygous B-FcRn KO mice. Mouse Fcgrt  mRNA was detectable in C57BL/6(+/+) mice but not the homozygous B-FcRn KO mice.

Protein expression analysis 

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Strain specific analysis of FcRn expression in C57BL/6(+/+)  and the homozygous B-FcRn KO mice by western blot.
Kidney was collected from C57BL/6(+/+) mice and homozygous B-FcRn KO mice. Mouse FcRn was detectable in C57BL/6(+/+) mice but not the homozygous B-FcRn KO mice.

FcRn-deficient mice have low serum IgG



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Sera from C57BL/6(+/+) mice and B-FcRn KO mice were analyzed by ELISA .