IFNGR1 also named CD119, IFNGR, IMD27A, IMD27B
IFNG gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. IFNγ has antiviral, immunoregulatory, and anti-tumor properties. It alters transcription in up to 30 genes producing a variety of physiological and cellular responses. IFNGR1 encodes the ligand-binding chain (alpha) of the gamma interferon receptor. IFNG2 encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR1 or IFNGR2 will cause of mendelian susceptibility to mycobacterial disease(MSMD), also known as familial disseminated atypical mycobacterial infection.
mRNA and Protein expression analysis