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B-hITGA4 mice
Strain Name

C57BL/6-Itga4tm1(ITGA4)/Bcgen

Common Name 

B-hITGA4 mice

Background C57BL/6 Catalog number  

110902


Related Genes 

integrin subunit alpha 4, CD49D, IA4


Gene description


ITGA4, also known as CD49d. The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. It has been shown to interact with LGALS8 and Paxillin. CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.

Protein expression analysis  

from clipboard


Strain specific ITGA4 expression analysis in WT and heterozygous B-hITGA4 mice by flow cytometry.  Splenocytes were collected from C57BL/6(+/+) and heterozygous B-hITGA4 (H/+) mice. Mouse ITGA4 was detectable both in C57BL/6(+/+) mice and heterozygous B-hITGA4 mice. Human ITGA4 was detectable in heterozygous B-hITGA4(H/+) mice but not C57BL/6(+/+) mice .