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B-hITGAV mice
Strain Name C57BL/6-Itgavtm1(ITGAV)/Bcgen Common Name  B-hITGAV mice
Background C57BL/6 Catalog number  110866
Related Genes 
integrin subunit alpha V, CD51, MSK8, VNRA, VTNR

Gene description

ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer, and prostate cancer. The mAbs intetumumab, and abituzumab target this protein which is found on some tumour cells.

Protein expression analysis


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Strain specific ITGAV expression analysis in heterozygous B-hITGAV mice by flow cytometry. 
Bone marrow cells were collected from C57BL/6 wild-type mice (+/+) and heterozygous B-hITGAV mice(H/+) and analyzed by flow cytometry with species-specific anti-ITGAV antibody. Mouse ITGAV was detectable in wild-type mice and heterozygous B-hITGAV mice. Human ITGAV was exclusively detectable in heterozygous B-hITGAV mice.