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B-hITGB1 mice
Strain Name C57BL/6-Itgb1tm1(ITGB1)/Bcgen Common Name  B-hITGB1 mice
Background C57BL/6 Catalog number  110901
Related Genes 
integrin subunit beta 1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB

Gene description

Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. It is the representative member of the integrin subfamily, and it has 12 α‐subunits that can be heterodimerized. It has been reported to be widely expressed on different cell types including stem cells, in tissues like blood, skin and especially in glandular organs like mammary glands. ITGB1 has multiple functions in cell adhesion, migration, and proliferation; thus, the phenotype of ITGB1‐KO mice is embryonic lethal. ITGB1 is also overexpressed in cancer cells and contributes to various malignant phenotypes, such as EMT and tumor metastasis.

Protein expression analysis 

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Strain specific ITGB1 expression analysis in heterozygous B-hITGB1 mice by flow cytometry. 

Splenocytes were collected from C57BL/6 wild-type mice (+/+) and heterozygous B-hITGB1 mice (H/+) analyzed by flow cytometry with species-specific anti-ITGB1 antibody. Mouse ITGB1 was detectable in wild-type mice and heterozygous B-hITGB1 mice (H/+). Human ITGB1 were exclusively detectable in heterozygous B-hITGB1.