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B-hPSMA mice
Strain Name C57BL/6-Il2rbtm2(IL2RB)/Bcgen Common Name  B-hPSMA mice
Background C57BL/6 Catalog number  110119
Related Genes 
PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase

Gene description



PSMA (prostate specific membrane antigen) is a 100kDa type II transmembrane glycoprotein carrying intra- and extracellular protein domains, belonging to the M28 peptidase family. Functionally, it exerts a folate hydrolase and neurocarboxy-peptidase activity. Expressed in the human prostate and at lower levels in the brain, spine, peripheral nervous system, kidney, small intestine, and the salivary gland. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartyl glutamate (NAAG), thereby releasing glutamate. Endothelial cells of the neovasculature of almost all solid tumors express PSMA but not cells in the neovasculature associated with normal tissues. Studies have shown that it is strong upregulation in prostate cancer cells, however, yielded PSMA-based imaging for the detection of metastatic disease in advanced prostate cancer. PSMA expression was further shown to correlate with prostate cancer grade and was substantiated as an independent predictive factor for tumor recurrence. Moreover, PSMA-based radioligand therapy has been established as a therapeutic regimen in metastasized prostate cancer.

Protein expression analysis



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IHC for human PSMA expression. Kidney tissues from wild-type (+/+) and B-hPSMA mice (H/H) were stained with an antibody specific for human PSMA, and only the kidney tubular epithelial cells from B-hPSMA mice (H/H) showed hPSMA expression. (C57BL/6-1: kidney tissues from C57BL/6 mice were only stained with anti-IgG antibody; Human,C57BL/6-2 and B-hPSMA mice kidney tissues were stained with anti-human PSMA antibody.)