B-hVLDLR mice
| Strain Name |
C57BL/6N-Vldlrtm1(VLDLR)Bcgen/Bcgen
|
Common Name | B-hVLDLR mice |
| Background | C57BL/6N | Catalog number |
111195 |
|
Aliases |
VLDLR: CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH | ||
Targeting strategy
The exons 2-17 of mouse Vldlr gene that encode the full-length protein were replaced by human VLDLR exons 2-17 in B-hVLDLR mice.
Strain specific analysis of VLDLR mRNA expression in wild-type C57BL/6N mice and B-hVLDLR mice by RT-PCR. Testis and brain RNA were isolated from wild-type C57BL/6N mice (+/+) and homozygous B-hVLDLR mice (H/H), then cDNA libraries were synthesized by reverse transcription, followed by PCR with mouse or human VLDLR primers. Mouse Vldlr mRNA was detectable only in wild-type C57BL/6N mice. Human VLDLR mRNA was detectable only in homozygous B-hVLDLR mice but not in wild-type mice.
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