Rheumatoid arthritis (RA) is a systemic autoimmune disease accompanied by synovial inflammation and destruction of joints. Collagen antibody-induced arthritis (CAIA), an antibody-mediated arthritis model dependent on neutrophil granulocytes. CAIA is an extension of the CIA model and is one of the most common models in the antibody-induced arthritis model1.
Biocytogen has established stable CAIA disease models in different strains of mice (C57BL/6, Balb/c), which can be used for pharmacodynamic evaluation of rheumatoid arthritis related drugs. Besides, several humanized models have been developed to which can be applied for pharmacodynamic evaluation of rheumatoid arthritis related drugs.
Tissue sections were either stained with (H&E) (A), and infiltrating inflammatory cells in the spinal cord (B) were scored.
Clinical score (C), weight change (D), incidence rates (E) of CAIA model based on C57BL/6 mice were recorded.
1. Manivel VA, Sohrabian A, Rönnelid J. Granulocyte-augmented chemokine production induced by type II collagen containing immune complexes is mediated via TLR4 in rheumatoid arthritis patients. Eur J Immunol 2016;46:2822–34. 10.1002/eji.201646496
1. Tateiwa, D., Yoshikawa, H. & Kaito, T. Cartilage and Bone Destruction in Arthritis: Pathogenesis and Treatment Strategy: A Literature Review. Cells 8, doi:10.3390/cells8080818 (2019).
2. McInnes IB, et al. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 7, 429-42 (2007).