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B-Il2rg KO rats
Strain Name 


SD-Il2rgtm1/Bcgen


Common Name 


B-Il2rg KO rats


Background SD Catalog number  210513
Related Genes 

CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1

Project background


Il2rg is known as the interleukin receptor common gamma chain, which is an important signaling component of many interleukin receptors, including those of interleukin-2, interleukin-4, interleukin-7 and interleukin-21. Mutations in this gene cause X-linked severe combined immunodeficiency. This rat can be used to support research in many areas including immunology, inflammation research, cancer research, xenograft/transplant host etc.


Targeting strategy

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Model validation and analysis

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Homozygous Il2rgtm1/Bcgen rats demonstrate significantly reduced mature T, B and NK cells in spleen.

Markedly diminished T cells, B cells and NK cells are proved in homozygous Il2rgtm1/Bcgenrats (Figure 1), the same as reported, and similar to the phenotype in homozygous Il2rg knockout mice.