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B-Rag2/IL2rg KO rats
Strain Name 


SD-Rag2tm1Il2rgtm1/Bcgen


Common Name 


B-Rag2/IL2rg KO rats


Background SD Catalog number  210512
Related Genes 

RAG-2, CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1

Project background


The recombinant-activating gene 2 (Rag2) plays an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the initiation of V(D)J recombination. Loss of Rag2 protein leads to no mature T and B cells, the critical components of the adaptive immune system. Il2rg is known as the interleukin receptor common gamma chain, which is an important signaling component of many interleukin receptors, including those of interleukin -2, interleukin -4, interleukin -7 and interleukin -21. Mutations in this gene cause X-linked severe combined immunodeficiency. This rat can be used to support research in many areas including immune system defections, virology research, inflammation research, cancer research, xenograft/transplant host etc.


Targeting strategy


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Model validation and analysis


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Homozygous B-Rag2/IL2rg rats demonstrate significantly reduced mature B cells and NK cells.