请输入关键字
请输入关键字
订购
*国家
中国
美国
*省份
*城市
*姓名
*电话
*单位
*职位
*邮箱
*请输入验证码
*验证码
B-Rag2 KO rats
Strain Name 


SD-Rag2tm1/Bcgen


Common Name 



B-Rag2 KO rats



Background SD Catalog number  210511
Related Genes 

RAG-2

Project background


The recombinant-activating gene 2 (Rag2) plays an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the initiation of V(D)J recombination. Loss of Rag2 protein leads to no mature T and B cells, the critical components of the adaptive immune system. This rat can be used to support research in many areas including immune system defections, virology research and cancer research etc.


Targeting strategy

from clipboard

Model validation and analysis


from clipboard


Homozygous Rag2tm1/Bcgen rat showed completely loss of Rag2 full length RNA in thymus.
Homozygous Rag2tm1/Bcgen rats demonstrate significantly reduced mature T and B cells, but increased NK cells.