B-NDG系列免疫缺陷小鼠|百奥赛图官网

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B-NDG系列免疫缺陷小鼠

产品编号	常规命名	应用领域
110586	B-NDG mice	Immune reconstitution, CDX, transplantation, drug evaluation
110586	B-NDG mice-PDX	Immune reconstitution, CDX, transplantation, drug evaluation
110587	B-NDG nude mice	Human immune system reconstitution
110601	B-NDG B2m KO mice plus	Reduce PBMC reconstitution GVHD response and prolong experimental window
110600	B-NDG hIL15 mice	Promote human NK cell differentiation
110599	B-NDG HLA-A2.1 mice	Vaccine study
110596	B-NDG hIL6 mice	Promotes human monocyte differentiation
110590	B-NDG hTHPO mice	Without irradiation, it reduces the damage caused by irradiation to mice
110604	B-NDG hSIRPA mice	Maintain progenitor capacity
120612	B-NDG hIL7/hIL15 mice	Promote differentiation of human T cells and NK cells
110603	B-NDG hSIRPA/hCD47 mice	Evaluation of pharmacodynamic and toxicity of CD47, SIRPA targeted drugs
120609	B-NDG hCSF1/hTHPO mice	Promote differentiation of human myeloid cells without irradiation
113550	B-NDG hFAP mice	This mouse model is suitable for the pharmacodynamics and safety evaluations of drugs targeting human FAP (e.g., anti-hFAP antibodies, FAP-CAR-T cells, radiolabeled FAP inhibitors), tumor microenvironment and fibrosis pathogenesis studies, imaging probe development.
112946	B-NDG MHC I/II DKO mice ad	This model can be used to study the mechanism of xeno-GvHD in vivo, the pathogenesis of immune-related diseases such as tumor, autoimmune and metabolic diseases, and to evaluate the efficacy of novel drugs .
114316	huPBMC-B-NDG MHC I/II DKO mice ad	This model can be used to study the mechanism of xeno-GvHD in vivo, the pathogenesis of immune-related diseases such as tumor, autoimmune and metabolic diseases, and to evaluate the efficacy of novel drugs .
113352	B-NDG hNTCP mice
112705	B-NDG MHC I/II DKO/hB7-H3 mice
113931	B-NDG hCRBN mice
114084	B-NDG MHC I/II DKO/hMSLN/hB7-H3 mice
112660	B-NDG hEPCAM mice
112959	B-NDG Fah KO mice
114031	huHSC-B-NDG hIL15, FcγR KO mice
112483	huPBMC-B-NDG MHC I/II DKO mice plus
113231	B-NDG hGPC3 mice
113220	B-NDG hHER3 mice
112704	B-NDG MHC I/II DKO/hMSLN mice
113178	B-NDG hTROP2 mice
112839	B-NDG FcγR KO mice
113801	B-NDG hTHPO/hSCF mice
110591	B-NDG hCSF1 mice
112869	B-NDG Flt3 KO mice	This product results in a high level of immune system reconstitution after the transplantation of hematopoietic stem cells, especially for DC cells.
112889	B-NDG hFLT3LG, Flt3 KO mice
113385	B-NDG hIL2 mice
112863	huHSC-B-NDG hCSF1/hTHPO mice
112484	huPBMC-B-NDG B2m KO mice plus
112474	B-NDG hB2M/HLA-A11.1 mice plus
112590	B-NDG Tg(RORγt-Il2rg) mice
112914	B-NDG Kit W41 mice
112874	B-NDG hB2M/HLA-A24.2 mice plus
112873	B-NDG hB2M/HLA-A3.1 mice plus
112774	B-NDG hALB/hFcRn mice
112864	huHSC-B-NDG hIL6 mice	Promote differentiation of human monocyte-macrophage
112480	huHSC-B-NDG hTHPO mice	Irradiation is not required to avoid damage to mice caused by irradiation
112479	huHSC-B-NDG MGMT3 mice	Promote differentiation of human myeloid cells；Irradiation is not required to avoid damage to mice caused by irradiation
112865	huHSC-B-NDG HLA-A2.1 mice	To verify the efficacy of HLA-A2.1 restricted vaccines；Promote the development of human CD8+ T cells
112451	B-NDG hB2M/HLA-A11.1 mice	To verify the efficacy of HLA-A11.1 restricted vaccines and antibody-based therapies；Promote the development of human CD8+ T cells
112560	B-NDG hB2M/HLA-A24.2 mice	To verify the efficacy of HLA-A24.2 restricted vaccines and antibody-based therapies；Promote the development of human CD8+ T cells
112450	B-NDG hB2M/HLA-A3.1 mice	To verify the efficacy of HLA-A3.1 restricted vaccines and antibody-based therapies；Promote the development of human CD8+ T cells
112256	B-NDG H2-K1/H2-D1 KO mice	No MHC class I molecule expression; Reduce GVHD and prolong the experimental window period; Improve the accuracy of efficacy verification
111982	B-NDG hALB mice	Used for pharmacological or pharmacokinetic studies of drugs that utilize albumin to extend their half-life
112653	B-NDG hIL15, FcγR KO mice	Promote differentiation of human NK cells；No mouse Fc receptor function
112478	huHSC-B-NDG hIL15 mice	Promote differentiation of human NK cells
112482	huNK-B-NDG hIL15 mice	Promote differentiation of human NK cells
112449	B-NDG hB2M/HLA-A2.1 mice plus	To verify the efficacy of HLA-A2.1 restricted vaccines and antibody-based therapies；Promote the development of human CD8+ T cells
112470	huHSC-B-NDG mice	Human immune system reconstitution, mainly T cells and B cells；reconstitutionl Human-derived cell or tissue engraftmentl Tumor research；Human disease model studyl Efficacy and toxicity verification for
112469	huPBMC-B-NDG mice	Human T cell reconstitution；Human-derived cell or tissue engraftment；Tumor researchl Human disease model study；Efficacy and toxicity verification for human targeted drugs
110593	B-NDG hGM-CSF mice	Promote differentiation of human myeloid cells；For mating with other humanized mice that promote myeloid cell differentiation to obtain multi-humanized mice
110598	B-NDG hairless mice	Hairless, easy to measure tumor
110597	B-NDG hIL7 mice	Promote differentiation of human lymphoid cells
110595	B-NDG H2-Ab1 KO mice	No MHC class II molecule expression; Reduce GVHD and prolong the experimental window period；Improve the accuracy of efficacy verification
111882	B-NDG MGMT3 mice	Promote differentiation of human myeloid cells；Irradiation is not required to avoid damage to mice caused by irradiatio
111895	B-NDG MHC I/II DKO mice plus	No MHC class I/II molecule expression；Reduce GVHD and prolong the experimental window period；Improve the accuracy of efficacy verification
111922	B-NDG hFcRn mice	PK (NDG background can reduce ADA)
111856	B-NDG B2m plus/hIL15 mice	Human immune system reconstitution
110605	B-NDG Hc mice	Antibody CDC function study

立足全球生物医药行业，从技术创新出发，百奥赛图建立“BioMice百奥动物”子品牌。百奥动物集创新动物模型研发制备、生产供应和实验服务为一体，拥有2800余个独特基因编辑动物/细胞系模型，覆盖肿瘤，自免，代谢等多个疾病领域。创新的动物模型、高标准的质量管理、多元化的服务平台，助推生物医药创新产业的快速发展。

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